Description

1-(Phenylsulphonyl)-4-Nitro-7-Azaindole-2-Carbaldehyde is a high-purity, advanced pharmaceutical intermediate characterized by its unique azaindole core functionalized with nitro and aldehyde groups. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of novel, biologically active molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Serves as a critical scaffold for structure-activity relationship (SAR) studies and the generation of focused compound libraries.
• Biochemical Probe Development: Used in the design and creation of chemical probes to study specific enzyme functions and signaling pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	1-(Phenylsulphonyl)-4-Nitro-7-Azaindole-2-Carbaldehyde
CAS No.	1227270-49-6
Molecular Formula	C₁₆H₁₁N₃O₅S
Molecular Weight	357.34 g/mol
Synonyms	4-Nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde; 1H-Pyrrolo[2,3-b]pyridine-2-carbaldehyde, 4-nitro-1-(phenylsulfonyl)-; 4-Nitro-1-tosyl-7-azaindole-2-carbaldehyde (common); 7-Azaindole-2-carbaldehyde, 4-nitro-1-(phenylsulfonyl)-; 1-Benzenesulfonyl-4-nitro-1H-pyrrolo[2,3-b]pyridine-2-carboxaldehyde
EINECS	Contact for details

Quality Control

Every batch of 1-(Phenylsulphonyl)-4-Nitro-7-Azaindole-2-Carbaldehyde is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity by HPLC, identity confirmation, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.