Description

n-Methyl-2-Pyridione-4-Boronic Ester is a specialized organoboron compound, specifically a pyridone-based boronic ester, serving as a crucial building block in modern synthetic chemistry. Its primary value lies in its role as a versatile intermediate in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This high-purity reagent is essential for research and development in the pharmaceutical and agrochemical industries, particularly for medicinal chemists and process development scientists working on novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing biaryl and heterobiaryl structures found in drug candidates.
• Agrochemical Synthesis: Used in the development of advanced active ingredients for crop protection products.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology: Employed in the synthesis of probes and ligands for studying biological targets and pathways.
• Process Chemistry: Utilized in the scale-up and optimization of synthetic routes for commercial manufacturing.
• Academic Research: A valuable reagent for methodological development in organic synthesis and catalysis studies.

Basic Information

Product Name	n-Methyl-2-Pyridione-4-Boronic Ester
CAS No.	1227068-65-6
Molecular Formula	C8H10BNO2
Molecular Weight	162.98 g/mol
Synonyms	1-Methyl-2-oxo-1,2-dihydropyridine-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methylpyridin-2(1H)-one; 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one; 4-Borono-1-methylpyridin-2(1H)-one pinacol ester; n-Methyl-2-pyridone-4-boronic acid pinacol ester; 1-Methyl-2-pyridone-4-boronic ester
EINECS	Contact for details

Quality Control

Our n-Methyl-2-Pyridione-4-Boronic Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.