Description

Ethyl 2-(5-Bromo-2-Methylphenyl)-2,2-Difluoroacetate is a high-value, multi-functional fluorinated building block essential for advanced organic synthesis. This compound is critical for introducing the difluoroacetate moiety into complex molecular architectures, enabling the development of novel materials and active ingredients. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing next-generation compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring difluoromethyl or difluoroacetate functional groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and pesticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Material Science Research: Serves as a monomer or modifying agent in the development of specialty polymers and fluorinated materials with unique surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands or organocatalysts for asymmetric synthesis applications.
• Chemical Biology Probes: Utilized as a building block for synthesizing fluorinated probes and tags used in medicinal chemistry and biochemical research.

Basic Information

Product Name	Ethyl 2-(5-Bromo-2-Methylphenyl)-2,2-Difluoroacetate
CAS No.	1226808-72-5
Molecular Formula	C11H11BrF2O2
Molecular Weight	293.11 g/mol
Synonyms	Ethyl 5-Bromo-2-methyl-α,α-difluorobenzeneacetate; 2-(5-Bromo-2-methylphenyl)-2,2-difluoroacetic Acid Ethyl Ester; Ethyl (5-Bromo-2-methylphenyl)difluoroacetate; Difluoro(5-bromo-2-methylphenyl)acetic Acid Ethyl Ester; 5-Bromo-2-methyl-α,α-difluorobenzeneacetic Acid Ethyl Ester; Ethyl 2,2-Difluoro-2-(5-bromo-2-methylphenyl)acetate
EINECS	Contact for details

Quality Control

Our Ethyl 2-(5-Bromo-2-Methylphenyl)-2,2-Difluoroacetate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider holding under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.