Description

3,3-Difluorocyclobutane-1,1-Dicarboxylic 1-Isopropyl Ester is a high-value, fluorinated cyclobutane derivative serving as a critical synthetic intermediate. Its unique structure, featuring a difluorocyclobutane core, makes it a versatile building block for introducing conformational rigidity and fluorine atoms into target molecules. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting metabolic diseases, CNS disorders, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and pesticides, where the fluorinated cyclobutane moiety can enhance biological activity and environmental stability.
• Advanced Material Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and liquid crystals with tailored thermal and chemical resistance properties.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research exploring new methodologies in fluorination and the construction of complex, strained ring systems.
• Ligand and Catalyst Development: Utilized in the design and synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis applications.

Basic Information

Product Name	3,3-Difluorocyclobutane-1,1-Dicarboxylic 1-Isopropyl Ester
CAS No.	1225532-90-0
Molecular Formula	C10H14F2O4
Molecular Weight	236.22 g/mol
Synonyms	1-Isopropyl 3,3-difluorocyclobutane-1,1-dicarboxylate; 3,3-Difluoro-1,1-cyclobutanedicarboxylic Acid 1-Isopropyl Ester; Isopropyl 3,3-difluoro-1-carboxycyclobutane-1-carboxylate; 1-(Isopropoxycarbonyl)-3,3-difluorocyclobutane-1-carboxylic Acid; Difluorocyclobutanedicarboxylic Acid Isopropyl Ester; 1225532-90-0; 3,3-Difluorocyclobutane-1,1-dicarboxylic Acid Mono-isopropyl Ester
EINECS	Contact for details

Quality Control

Our 3,3-Difluorocyclobutane-1,1-Dicarboxylic 1-Isopropyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to cGMP principles and ISO-aligned procedures guarantees a reliable supply of high-purity material for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The ester functionality suggests it should be kept away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.