Description

Diisopropyl 3,3-Difluorocyclobutane-1,1-Dicarboxylate is a high-value fluorinated cyclobutane derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique difluorocyclobutane core offers a rigid, lipophilic scaffold with altered electronic properties, making it indispensable for modulating the physicochemical characteristics of target molecules. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases, where the difluorocyclobutane moiety can enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides, where the fluorine atoms and cyclobutane ring contribute to improved biological activity and environmental profile.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and liquid crystals with tailored thermal, optical, and chemical resistance properties.
• Fluorine Chemistry Research: An essential reagent for academic and industrial laboratories exploring new fluorination methodologies, cyclobutane ring transformations, and the construction of complex, fluorinated molecular architectures.
• Ligand and Catalyst Development: Utilized in the preparation of novel chiral ligands and organocatalysts for asymmetric synthesis, leveraging the steric and electronic influence of the difluorocyclobutane group.

Basic Information

Product Name	Diisopropyl 3,3-Difluorocyclobutane-1,1-Dicarboxylate
CAS No.	1225532-89-7
Molecular Formula	C12H18F2O4
Molecular Weight	264.27 g/mol
Synonyms	3,3-Difluorocyclobutane-1,1-dicarboxylic Acid Diisopropyl Ester; Diisopropyl 3,3-Difluoro-1,1-cyclobutanedicarboxylate; 1,1-Bis(isopropoxycarbonyl)-3,3-difluorocyclobutane; 3,3-Difluorocyclobutane-1,1-dicarboxylic Acid Bis(1-methylethyl) Ester; Difluorocyclobutane Diisopropyl Diester
EINECS	Contact for details

Quality Control

Our Diisopropyl 3,3-Difluorocyclobutane-1,1-Dicarboxylate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including NMR, HPLC, and GC, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be moisture-sensitive; keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.