Description

2-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and novel functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of novel pesticides, herbicides, and fungicides by enabling the introduction of the thiazole-phenyl moiety.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs or components for conductive polymers.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and bioconjugates for diagnostic and research applications.
• Academic & Industrial R&D: A versatile reagent for methodological development in cross-coupling chemistry and heterocyclic compound synthesis.
• Ligand Synthesis for Catalysis: Acts as a starting material for preparing sophisticated ligand systems used in homogeneous catalysis.

Basic Information

Product Name	2-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole
CAS No.	1225053-33-7
Molecular Formula	C15H18BNO2S
Molecular Weight	287.19 g/mol
Synonyms	2-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-phenylthiazole; 2-Phenylthiazole-4-boronic acid pinacol ester; 4-(Pinacolatoboryl)-2-phenylthiazole; 2-Phenyl-4-(pinacolboranyl)thiazole; 1225053-33-7; Thiazole boronic ester derivative
EINECS	Contact for details

Quality Control

Our 2-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of our global pharmaceutical and fine chemical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability, although the product is stable at room temperature for short periods under the recommended conditions. Keep container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.