Description

2-Phenyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Thiazole is a high-value organoboron building block, specifically a boronic ester derivative of a phenylthiazole scaffold. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for forming carbon-carbon bonds. It is primarily sought after by pharmaceutical researchers, agrochemical developers, and material scientists for constructing complex molecules in drug discovery and advanced material synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science & OLED Development: Serves as a precursor for creating advanced organic electronic materials, including emissive layers in OLED displays and lighting.
• Ligand & Catalyst Design: Incorporated into novel ligands for transition metal catalysts used in asymmetric synthesis and other specialized reactions.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological pathways and target engagement.
• Polymer & Dendrimer Chemistry: Enables the modular construction of functional polymers and dendritic structures with precise architecture.

Basic Information

Item	Details
Product Name	2-Phenyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Thiazole
CAS No.	1225053-32-6
Molecular Formula	C15H18BNO2S
Molecular Weight	287.19 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-phenylthiazole; 2-Phenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 2-Phenylthiazole-5-boronic acid pinacol ester; (2-Phenylthiazol-5-yl)boronic acid pinacol ester; Thiazole-5-boronic acid, 2-phenyl-, 1,1-dimethylethyl ester; CAS 1225053-32-6
EINECS	Contact for details

Quality Control

Every batch of our 2-Phenyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Thiazole undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, meeting the stringent requirements of research and process chemistry. Our quality systems are designed to support cGMP and ISO standards for advanced intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.