Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2Yl)Benzo[D]Oxazol-2-Amine is a high-purity, advanced pharmaceutical intermediate and building block featuring a benzoxazole core and a pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and organic electronic materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boron-containing coupling partner for the formation of carbon-carbon bonds with aryl/heteroaryl halides.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science: A precursor for creating organic semiconductors, OLED materials, and other functional polymers.
• Chemical Biology: Employed in the synthesis of probes and ligands for target identification and validation in biological systems.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2Yl)Benzo[D]Oxazol-2-Amine
CAS No.	1224844-66-9
Molecular Formula	C15H21BN2O3
Molecular Weight	288.15 g/mol
Synonyms	2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoxazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-benzoxazolamine; 2-Amino-5-(pinacolatoboryl)benzoxazole; 5-(Pinacolboron)benzoxazol-2-amine; Benzo[d]oxazol-2-amine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1224844-66-9; 5-(Pinacolatoboryl)-2-aminobenzoxazole
EINECS	Contact for details

Quality Control

Our 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2Yl)Benzo[D]Oxazol-2-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.