Description

5-Bromo-1-Fluoro-2-Methoxy-3-(Trifluoromethyl)Benzene is a high-value, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique combination of bromo, fluoro, methoxy, and trifluoromethyl substituents makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), due to its ability to modify molecular polarity and mesomorphic properties.
• Polymer & Specialty Chemicals: Employed as a monomer or modifier in the synthesis of high-performance polymers, coatings, and specialty chemicals requiring specific halogenated aromatic structures.
• Cross-Coupling Reactions: The bromine atom provides an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl systems.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic methodologies and constructing molecular libraries for screening.

Basic Information

Product Name	5-Bromo-1-Fluoro-2-Methoxy-3-(Trifluoromethyl)Benzene
CAS No.	1224604-21-0
Molecular Formula	C9H5BrF4O
Molecular Weight	285.04 g/mol
Synonyms	1-Bromo-4-fluoro-5-methoxy-2-(trifluoromethyl)benzene; 5-Bromo-1-fluoro-2-methoxy-3-(trifluoromethyl)benzene; 2-Bromo-5-fluoro-4-methoxy-α,α,α-trifluorotoluene; 3-Bromo-6-fluoro-5-methoxybenzotrifluoride; Benzene, 5-bromo-1-fluoro-2-methoxy-3-(trifluoromethyl)-; 5-Bromo-1-fluoro-2-methoxy-α,α,α-trifluorotoluene; BFM-TFMB (common abbreviation)
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-1-Fluoro-2-Methoxy-3-(Trifluoromethyl)Benzene adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.