Description

Fmoc-4-(4-Fluorophenyl)-L-Phenylalanine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is engineered to introduce a fluorinated biphenyl moiety into peptide chains, a critical modification for enhancing binding affinity and metabolic stability in therapeutic candidates. It is an essential building block for pharmaceutical R&D teams and CROs focused on developing novel peptide-based drugs, diagnostics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, enabling the controlled assembly of complex peptide sequences.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs) targeting GPCRs, kinases, and other protein-protein interactions.
• Peptidomimetic Design: Incorporates a rigid, hydrophobic fluorinated aromatic system to mimic protein secondary structure and improve drug-like properties.
• Chemical Biology Probes: Serves as a building block for creating labeled or tagged peptides used in target identification and validation studies.
• Antibody-Drug Conjugate (ADC) Linker/Payload Research: Potential use in constructing specialized amino acid components for novel linker systems.
• Material Science: Research into self-assembling peptide materials and bio-conjugates where fluorination alters surface properties.

Basic Information

Product Name	Fmoc-4-(4-Fluorophenyl)-L-Phenylalanine
CAS No.	1223105-46-1
Molecular Formula	C₃₁H₂₆FNO₄
Molecular Weight	495.54 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(4-fluorophenyl)-L-phenylalanine; Fmoc-4-(4-Fluorophenyl)-L-Phe-OH; Nα-Fmoc-4'-(4-fluorophenyl)-L-phenylalanine; Fmoc-L-4-(4-Fluorophenyl)phenylalanine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-([1,1'-biphenyl]-4-yl)phenyl)propanoic acid (related IUPAC); Fmoc-4-(4-Fluorobiphenyl-4-yl)-L-alanine (common abbreviation); Boc-4-(4-Fluorophenyl)-L-Phenylalanine (related Boc-protected variant)
EINECS	Contact for details

Quality Control

Every batch of Fmoc-4-(4-Fluorophenyl)-L-Phenylalanine is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent in-house specifications tailored for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥95% by HPLC), and impurity profiles. Our quality commitment supports applications requiring traceability and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccation and an inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.