Description

n-(8α,9S)-Cinchonan-9-Yl-N'-[(2S)-2-Pyrrolidinylmethyl]-Thiourea is a sophisticated chiral thiourea derivative, structurally derived from cinchona alkaloids, designed for high-performance asymmetric catalysis and molecular recognition. This compound is valued for its role as a potent organocatalyst, enabling enantioselective transformations critical for producing single-isomer pharmaceutical intermediates and fine chemicals. It is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical sectors who require precise stereochemical control in synthetic pathways.

Application

• As a chiral organocatalyst for enantioselective synthesis, including Michael additions, Mannich reactions, and acylations.
• In the pharmaceutical industry for the research and development of active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• As a key component in ligand libraries for screening in asymmetric metal catalysis and combinatorial chemistry.
• For the development of molecular sensors and receptors due to its hydrogen-bonding thiourea moiety and chiral recognition sites.
• In academic and industrial R&D for methodological studies in organic synthesis and catalysis.
• Potential use in the synthesis of agrochemicals and other bioactive compounds where chirality impacts efficacy.

Basic Information

Product Name	n-(8α,9S)-Cinchonan-9-Yl-N'-[(2S)-2-Pyrrolidinylmethyl]-Thiourea
CAS No.	1222966-34-8
Molecular Formula	C₂₅H₃₂N₄OS
Molecular Weight	436.61 g/mol
Synonyms	(8α,9S)-N-[(2S)-2-Pyrrolidinylmethyl]-9-cinchonanamine, 1-[(2S)-2-Pyrrolidinylmethyl]-3-[(8α,9S)-cinchonan-9-yl]thiourea; Cinchona Alkaloid Thiourea Derivative; Chiral Cinchona Thiourea Organocatalyst; (S,S)-Cinchona-Pyrrolidine Thiourea Catalyst; Asymmetric Organocatalyst 1222966-34-8; N-[(8α,9S)-Cinchonan-9-yl]-N'-[(2S)-2-pyrrolidinylmethyl]thiourea
EINECS	Contact for details

Quality Control

Our production of this high-value chiral compound adheres to stringent quality control protocols to ensure batch-to-batch consistency and purity for catalytic performance. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral purity is provided with every shipment, supporting compliance with research and cGMP development standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere if necessary to prevent degradation. Keep the container sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.