Description

4-Bromo-2-(cyclopropylcarbonyl)-1-fluorobenzene is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters because it offers a unique combination of reactive handles—bromine, fluorine, and a carbonyl group—enabling precise molecular construction for complex target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging its fluorinated aromatic structure for enhanced bioactivity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form biaryl structures.
• Fluorine Chemistry Studies: Utilized in research to study the influence of fluorine atoms on the reactivity, stability, and physicochemical properties of aromatic systems.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing complex chelating ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Bromo-2-(cyclopropylcarbonyl)-1-fluorobenzene
CAS No.	1222368-75-3
Molecular Formula	C10H8BrFO
Molecular Weight	243.07 g/mol
Synonyms	1-Bromo-4-fluoro-2-(cyclopropanecarbonyl)benzene; 2-Bromo-5-fluorophenyl cyclopropyl ketone; 4-Bromo-2-cyclopropylcarbonyl-1-fluorobenzene; (4-Bromo-2-fluorophenyl)(cyclopropyl)methanone; Cyclopropyl(4-bromo-2-fluorophenyl)methanone; 1222368-75-3
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(cyclopropylcarbonyl)-1-fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.