Description

1-(4-(4-tert-Butylthiazol-2-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)-3-Ethylurea is a high-value, multi-functional organic building block featuring a boronic ester pinacol group and a urea linkage. This compound is engineered to serve as a critical intermediate in modern synthetic chemistry, enabling efficient cross-coupling reactions and the construction of complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides, leveraging its boronic ester functionality for efficient carbon-carbon bond formation.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and sensors, due to its conjugated system.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific boronic ester derivatives.
• Academic & Industrial R&D: Essential for methodological development in organic synthesis and catalysis studies within university and corporate laboratories.

Basic Information

Product Name	1-(4-(4-tert-Butylthiazol-2-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)-3-Ethylurea
CAS No.	1221969-67-0
Molecular Formula	C21H31BN4O3S
Molecular Weight	430.37 g/mol
Synonyms	3-Ethyl-1-[4-(4-tert-butyl-1,3-thiazol-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]urea; 1-(4-(4-(tert-Butyl)thiazol-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)-3-ethylurea; (2-(3-Ethylureido)-5-(4-(tert-butyl)thiazol-2-yl)pyridin-3-yl)boronic acid pinacol ester; B-[2-(3-Ethylureido)-5-[4-(1,1-dimethylethyl)-2-thiazolyl]-3-pyridinyl]boronic acid, pinacol ester; CAS 1221969-67-0
EINECS	Contact for details

Quality Control

Every batch of 1-(4-(4-tert-Butylthiazol-2-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)-3-Ethylurea is produced and analyzed under strict quality management protocols. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.