Description

2-Bromo-1-(2,3-Difluoro-4-Methylphenyl)Ethan-1-One, also known as 2-Bromo-2',3'-Difluoro-4'-Methylacetophenone, is a high-purity, specialized organic intermediate of significant importance in advanced chemical synthesis. Its precise molecular architecture, featuring bromine and fluorine substituents on an acetophenone core, makes it a critical building block for constructing complex molecules. This compound is primarily sought by R&D and production teams in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

This versatile brominated difluoroacetophenone derivative serves as a key synthetic precursor in several high-value industrial applications:

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex drug candidates, particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethyl and bromoacetyl groups contribute to biological activity.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals, where its specific halogenated structure can influence material properties.
• Organic Synthesis Reagent: Functions as an electrophilic agent in Friedel-Crafts acylation-type reactions and cross-coupling reactions for introducing functionalized acetyl groups.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Item	Detail
Product Name	2-Bromo-1-(2,3-Difluoro-4-Methylphenyl)Ethan-1-One
CAS No.	1221684-44-1
Molecular Formula	C9H7BrF2O
Molecular Weight	249.06 g/mol
Synonyms	2-Bromo-2',3'-Difluoro-4'-Methylacetophenone; 1-(2,3-Difluoro-4-methylphenyl)-2-bromoethanone; 2-Bromo-1-(2,3-difluoro-4-methylphenyl)ethanone; α-Bromo-2,3-difluoro-4-methylacetophenone; 2-Bromo-2,3-difluoro-4-methylacetophenone; Bromo(2,3-difluoro-4-methylphenyl)methanone (incorrect but common search variant); Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(2,3-Difluoro-4-Methylphenyl)Ethan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.