Description

5-Methyl-3-Oxo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine-6-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate belonging to the class of protected boronic acid derivatives. This compound is critically important as a key building block in modern synthetic chemistry, particularly for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of complex drug candidates, particularly those containing the benzoxazine core structure.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a versatile organoboron partner for palladium-catalyzed carbon-carbon bond formation, essential for constructing biaryl and heterobiaryl systems in medicinal chemistry.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science: Potential building block for creating organic electronic materials and functional polymers with tailored properties.
• Chemical Biology & Proteomics: Can be employed as a molecular probe or linker in the development of activity-based probes and bioconjugation strategies.
• Academic & Contract Research: A valuable reagent for synthetic methodology development and exploratory research in organic chemistry laboratories worldwide.

Basic Information

Product Name	5-Methyl-3-Oxo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine-6-Boronic Acid Pinacol Ester
CAS No.	1221502-31-3
Molecular Formula	C₁₅H₂₀BNO₄
Molecular Weight	289.14 g/mol
Synonyms	5-Methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-boronic acid pinacol ester; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one; 5-Methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-boronic acid pinacol ester; 5-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one; Benzo[b][1,4]oxazin-3(4H)-one, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-methyl-; CAS 1221502-31-3
EINECS	Contact for details

Quality Control

Our 5-Methyl-3-Oxo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine-6-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (by NMR)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.