Description

5-Fluoro-3-Oxo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine-6-Boronic Acid Pinacol Ester is a high-value, multifunctional heterocyclic building block designed for advanced organic synthesis. This compound is critical for enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental to constructing complex molecular architectures. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing the benzoxazine scaffold with potential biological activity.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its fluorine and boronic ester functional groups.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as OLEDs and semiconductors, due to its conjugated system.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronic ester group makes it an ideal, stable partner for palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Medicinal Chemistry & Drug Discovery: Enables rapid parallel synthesis and library generation for high-throughput screening against various biological targets.
• Chemical Biology Probes: Used to create tagged molecules for studying biological processes and protein interactions.

Basic Information

Product Name	5-Fluoro-3-Oxo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine-6-Boronic Acid Pinacol Ester
CAS No.	1221496-98-5
Molecular Formula	C₁₄H₁₅BFNO₄
Molecular Weight	291.09 g/mol
Synonyms	5-Fluoro-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-boronic acid pinacol ester; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one; 5-Fluoro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-boronic acid, pinacol ester; Benzo[b][1,4]oxazin-3(4H)-one, 5-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1221496-98-5; 5-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one
EINECS	Contact for details

Quality Control

Our 5-Fluoro-3-Oxo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine-6-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent hydrolysis of the boronic ester moiety. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.