Description

3-Trifluoromethyl-Azetidine is a versatile and high-value fluorinated heterocyclic building block. Its unique structure, featuring a saturated azetidine ring substituted with a strongly electron-withdrawing trifluoromethyl group, makes it a critical intermediate for modulating the physicochemical properties of advanced molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical sectors seeking to enhance metabolic stability, lipophilicity, and bioavailability in their target compounds. The CAS number for this product is 1221349-18-3.

Application

The primary utility of 3-Trifluoromethyl-Azetidine lies in its role as a sophisticated synthon for introducing fluorinated, nitrogen-containing ring systems. Key application areas include:

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug discovery programs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the trifluoromethyl-azetidine moiety can improve biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating specialty polymers and advanced materials with specific surface properties or chemical resistance.
• Ligand & Catalyst Development: Employed in the design of novel ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable substrate for studying the reactivity of fluorinated small-ring heterocycles and developing new fluorination methodologies.

Basic Information

Product Name	3-Trifluoromethyl-Azetidine
CAS No.	1221349-18-3
Molecular Formula	C4H6F3N
Molecular Weight	125.09 g/mol
Synonyms	3-(Trifluoromethyl)azetidine; Azetidine, 3-(trifluoromethyl)-; 3-Trifluoromethylazetidine; 3-(Trifluoromethyl)-1-azacyclobutane; 1-Azacyclobutane, 3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our fluorinated building blocks. Each batch of 3-Trifluoromethyl-Azetidine is analyzed using advanced techniques including GC, HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. Our quality management system is designed to meet the exacting standards of cGMP and ISO-guided environments for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.