Description

Methyl 3-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)-4-Methylbenzoate is a high-purity, synthetically valuable boronic ester derivative, serving as a crucial advanced pharmaceutical intermediate and building block in modern organic synthesis. Its core value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental for constructing complex molecular architectures. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the formation of carbon-carbon bonds for constructing biaryl and heterobiaryl structures prevalent in many active pharmaceutical ingredients (APIs).
• Material Science Research: Used in the development of organic electronic materials, such as OLEDs and organic semiconductors, where precise molecular architecture is required.
• Agrochemical Synthesis: Intermediate for creating advanced crop protection agents with specific activity profiles.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	Methyl 3-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)-4-Methylbenzoate
CAS No.	1221343-13-0
Molecular Formula	C15H21BO4
Molecular Weight	276.14 g/mol
Synonyms	3-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-4-methylbenzoic acid methyl ester; Methyl 3-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-p-toluate; 4-Methyl-3-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzoic acid methyl ester; 5,5-Dimethyl-2-[2-(methoxycarbonyl)-5-methylphenyl]-1,3,2-dioxaborinane; MIDA Boronate Ester Derivative; Arylboronic Acid MIDA Ester
EINECS	Contact for details

Quality Control

Our Methyl 3-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)-4-Methylbenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring suitability for demanding pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.