Description

1-Chloro-3-(3,5-Difluorophenyl)Propan-2-One is a high-value fluorinated aromatic ketone building block, essential for constructing complex molecular architectures in advanced chemical synthesis. Its unique structure, featuring both a reactive chloroacetone moiety and a difluorophenyl ring, makes it a critical intermediate for introducing specific pharmacophores. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, where the difluorophenyl group enhances biological activity and stability.
• Material Science Research: Serves as a precursor for synthesizing specialized monomers or ligands used in advanced polymers and metal-organic frameworks (MOFs).
• Organic Synthesis & Process Chemistry: A versatile reagent for constructing complex organic molecules via nucleophilic substitution and further functionalization of the ketone group.

Basic Information

Product Name	1-Chloro-3-(3,5-Difluorophenyl)Propan-2-One
CAS No.	1221343-06-1
Molecular Formula	C9H7ClF2O
Molecular Weight	204.60 g/mol
Synonyms	3,5-Difluorophenacyl Chloride; 1-Chloro-3-(3,5-difluorophenyl)acetone; 2-Propanone, 1-chloro-3-(3,5-difluorophenyl)-; 3,5-Difluorophenyl Chloromethyl Ketone; (3,5-Difluorophenyl)chloromethyl Ketone; 2-Chloro-1-(3,5-difluorophenyl)ethanone (tautomeric form); α-Chloro-3,5-difluoroacetophenone
EINECS	Contact for details

Quality Control

Our 1-Chloro-3-(3,5-Difluorophenyl)Propan-2-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.