Description

3-Chloro-4',5'-Difluorophenylpropanone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in its unique molecular scaffold, which incorporates chlorine and fluorine substituents to enable precise modulation of electronic and steric properties in target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoro and chloro groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a building block for creating specialized polymers, liquid crystals, and organic electronic materials with tailored properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	3-Chloro-4',5'-Difluorophenylpropanone
CAS No.	1221342-53-5
Molecular Formula	C9H7ClF2O
Molecular Weight	204.60 g/mol
Synonyms	1-(3-Chloro-4,5-difluorophenyl)propan-1-one; 3-Chloro-4,5-difluoropropiophenone; 3'-Chloro-4',5'-difluoropropiophenone; 1-Propanone, 1-(3-chloro-4,5-difluorophenyl)-; 3-Chloro-4,5-difluorophenyl ethyl ketone
EINECS	Contact for details

Quality Control

Our 3-Chloro-4',5'-Difluorophenylpropanone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.