Description

(2R)-2-(Trifluoromethyl)Azetidine is a high-purity, chiral azetidine building block featuring a strategically positioned trifluoromethyl group. This compound matters as a critical intermediate for medicinal chemistry and agrochemical research, enabling the synthesis of novel molecules with enhanced metabolic stability, lipophilicity, and bioavailability. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing advanced active ingredients, particularly in the areas of protease inhibitors, kinase modulators, and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, especially in oncology, CNS disorders, and antiviral therapies.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides where the CF3 group confers desirable biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Incorporated into specialty polymers and advanced materials to modify surface properties and chemical resistance.
• Fluorine Chemistry Library Building: An essential component for constructing diverse compound libraries focused on fluorine-containing molecules for high-throughput screening.

Basic Information

Product Name	(2R)-2-(Trifluoromethyl)Azetidine
CAS No.	1221266-24-5
Molecular Formula	C4H6F3N
Molecular Weight	125.09 g/mol
Synonyms	(R)-2-(Trifluoromethyl)azetidine; (2R)-2-(Trifluoromethyl)azetidine; Azetidine, 2-(trifluoromethyl)-, (2R)-; (R)-2-Trifluoromethylazetidine; (R)-2-(Trifluoromethyl)azetidine; 1221266-24-5; (R)-2-(Trifluoromethyl)azetidine hydrochloride (if applicable)
EINECS	Contact for details

Quality Control

Our (2R)-2-(Trifluoromethyl)Azetidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR, and GC/HPLC for purity assessment, to ensure compliance with exacting R&D and production standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, guaranteeing traceability and batch-to-batch consistency for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to strong bases and fluorides, keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.