Description

1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-2-One is a high-value, protected boronic ester derivative of an indolinone scaffold, serving as a critical synthetic intermediate. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry and materials science. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require a reliable, high-purity building block for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and oncology research programs.
• Agrochemical Development: Used in the research and production of advanced active ingredients for crop protection.
• Material Science Research: Serves as a precursor for organic electronic materials, including OLEDs and semiconductors.
• Chemical Biology Probes: Enables the creation of tagged molecules for studying biological pathways and target engagement.
• Library Synthesis: Facilitates the rapid generation of diverse compound libraries for high-throughput screening in drug discovery.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for commercial active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-2-One
CAS No.	1220696-38-7
Molecular Formula	C15H20BNO3
Molecular Weight	273.14 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methylindolin-2-one; 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-indolinone; 1-Methyl-5-(pinacolatoboryl)indolin-2-one; 5-(Pinacolatoboraneyl)-1-methylindolin-2-one; 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one; 1-Methyl-5-(pinacolboron)oxindole; 5-(Pinacolboron)-1-methyloxindole; 1220696-38-7
EINECS	Contact for details

Quality Control

Our 1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Indolin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.