Description

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine is a high-value, heterocyclic boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process R&D teams developing novel active pharmaceutical ingredients (APIs), agrochemicals, and organic electronic materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, particularly kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used to construct novel heterocyclic scaffolds for the development of new pesticides and herbicides.
• Material Science: Building block for creating organic semiconductors, light-emitting diodes (OLEDs), and other functional organic materials.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and bioconjugation reagents for target identification and validation.
• Academic & Contract Research: Fundamental reagent for methodological development in cross-coupling chemistry and heterocycle functionalization.
• Scale-up & Process Chemistry: Suitable for route scouting and optimization from milligram to kilogram scale for clinical trial material production.

Basic Information

Product Name	1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine
CAS No.	1220696-34-3
Molecular Formula	C14H19BN2O2
Molecular Weight	258.13 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-pyrrolo[2,3-b]pyridine; 1-Methyl-1H-pyrrolo[2,3-b]pyridine-5-boronic acid pinacol ester; 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7-azaindole; 1-Methyl-5-borono-1H-pyrrolo[2,3-b]pyridine pinacol ester; 5-Borono-1-methyl-1H-pyrrolo[2,3-b]pyridine pinacol ester; 1-Methyl-7-azaindole-5-boronic acid pinacol ester; 1-Methyl-1H-pyrrolo[2,3-b]pyridin-5-ylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.