Description

3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2(3H)-Benzoxazolone is a high-value, organoboron building block essential for modern synthetic chemistry, particularly in cross-coupling reactions. Its core value lies in enabling the efficient and precise construction of complex molecular architectures, which is critical for developing new active compounds. This advanced intermediate is primarily needed by research and development teams in the pharmaceutical and agrochemical industries, where it serves as a key precursor for creating novel drug candidates and crop protection agents.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A pivotal reagent for forming carbon-carbon bonds to construct biaryl and heterobiaryl structures in medicinal chemistry.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Agrochemical Synthesis: Serves as a building block for developing new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, due to its conjugated benzoxazolone core.
• Chemical Biology & Probe Development: Utilized for synthesizing molecular probes and labeled compounds for biological imaging and mechanism studies.
• Library Synthesis for Drug Discovery: A valuable scaffold for generating diverse compound libraries in high-throughput screening campaigns.

Basic Information

Product Name	3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2(3H)-Benzoxazolone
CAS No.	1220696-32-1
Molecular Formula	C₁₆H₂₂BNO₄
Molecular Weight	303.16 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methyl-2(3H)-benzoxazolone; 3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzoxazol-2(3H)-one; 2(3H)-Benzoxazolone, 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 3-Methyl-5-(pinacolatoboron)benzoxazol-2(3H)-one; 5-Pinacolatoboron-3-methyl-2-benzoxazolone
EINECS	Contact for details

Quality Control

Our 3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2(3H)-Benzoxazolone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to relevant cGMP and ISO guidelines for the production of advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.