Description

1-[(Tetrahydro-2H-Pyran-4-Yl)Methyl]-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-value, multi-functional heterocyclic boronic ester derivative, serving as a critical advanced pharmaceutical intermediate and Suzuki-Miyaura cross-coupling building block. Its unique molecular architecture, featuring a protected boronate ester and a pyrazole core linked to a tetrahydropyranylmethyl group, enables precise and efficient carbon-carbon bond formation under mild conditions. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and material science sectors seeking to synthesize complex molecules for drug discovery and fine chemical production.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the efficient formation of biaryl and heterobiaryl linkages, a cornerstone reaction in modern medicinal chemistry and material science.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science & OLED Research: A valuable monomer for constructing complex organic frameworks, polymers, and electron-transport materials for organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed in the design and synthesis of bifunctional molecules for targeted protein degradation.
• Library Synthesis for High-Throughput Screening: Facilitates the rapid generation of diverse compound libraries to accelerate hit identification in drug discovery programs.

Basic Information

Item	Details
Product Name	1-[(Tetrahydro-2H-Pyran-4-Yl)Methyl]-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1220635-60-8
Molecular Formula	C15H25BN2O3
Molecular Weight	292.19 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-pyrazole; 1-(Tetrahydro-2H-pyran-4-ylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 1-((Tetrahydro-2H-pyran-4-yl)methyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; THP-Pyrazole-BPin; 4-Pinacolatoboron-1-(tetrahydropyran-4-ylmethyl)pyrazole; Pyrazole boronic ester pinacol derivative; 1H-Pyrazole, 1-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Every batch of our 1-[(Tetrahydro-2H-Pyran-4-Yl)Methyl]-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling reactions and pharmaceutical synthesis. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.