Description

Methyl 2,6-Dimethoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinate CAS NO 1220423-76-6 is a high-value, multi-functional chemical building block featuring a protected boronic ester group on a substituted nicotinate core. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for forming carbon-carbon bonds. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of complex heterocyclic molecules and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require complex pyridine derivatives.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Medicinal Chemistry: Employed in the discovery and optimization of drug candidates through structure-activity relationship (SAR) studies and library synthesis.
• Catalyst & Ligand Development: Used to synthesize novel bidentate or tridentate ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A critical reagent for fine chemical manufacturers offering bespoke synthesis services for clients in life sciences.

Basic Information

Item	Detail
Product Name	Methyl 2,6-Dimethoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinate
CAS No.	1220423-76-6
Molecular Formula	C17H26BNO6
Molecular Weight	351.21 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-dimethoxynicotinic acid methyl ester; Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-dimethoxynicotinate; 2,6-Dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinic acid methyl ester; 1220423-76-6; Pinacol boronate ester of methyl 5-bromo-2,6-dimethoxynicotinate; Nicotinic acid boronate derivative
EINECS	Contact for details

Quality Control

Our production of Methyl 2,6-Dimethoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR (1H, 13C, 11B), HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.