Description

(2R)- 2-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]-5-(Trimethylsilyl)-4-Pentynal is a high-value, chiral synthetic intermediate featuring both tert-butyldiphenylsilyl (TBDPS) and trimethylsilyl (TMS) protecting groups. This compound matters for its precise stereochemistry and functional group arrangement, making it a critical building block for the controlled synthesis of complex molecules. It is primarily needed by research and development teams in the pharmaceutical and advanced organic synthesis sectors for constructing active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Serves as a crucial building block for constructing stereocenters in natural product synthesis and medicinal chemistry.
• Peptidomimetic Research: Used in the development of peptide analogs and conformationally restricted bioactive molecules.
• Protecting Group Strategy: The TBDPS and TMS groups allow for selective deprotection and further functionalization in complex synthetic routes.
• Academic & Industrial R&D: Employed in research laboratories for developing new synthetic methodologies and exploring chemical space.
• Fine Chemical Production: Intermediate in the manufacture of specialty chemicals requiring high stereochemical purity.

Basic Information

Item	Details
Product Name	(2R)- 2-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]-5-(Trimethylsilyl)-4-Pentynal
CAS No.	1220354-17-5
Molecular Formula	C24H32O2Si2
Molecular Weight	408.69 g/mol
Synonyms	(2R)-2-[(tert-Butyldiphenylsilyl)oxy]-5-(trimethylsilyl)-4-pentynal; (R)-2-((tert-Butyldiphenylsilyl)oxy)-5-(trimethylsilyl)pent-4-ynal; TBDPS-protected chiral pentynal; (R)-TBDPS-O-Protected TMS-alkynyl aldehyde; CAS 1220354-17-5; (2R)-2-[(Tert-butyldiphenylsilyl)oxy]-5-(trimethylsilyl)-4-pentyn-1-al; Chiral silyl-protected alkynyl aldehyde intermediate
EINECS	Contact for details

Quality Control

Our (2R)- 2-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]-5-(Trimethylsilyl)-4-Pentynal is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided to guarantee reproducible performance in your synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a freezer to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.