Description

2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone methodology for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to synthesize novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of new pesticides and herbicides, enabling the introduction of the nicotinonitrile scaffold into active molecules.
• Material Science Research: Serves as a precursor for creating functional organic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Chemical Biology & Proteomics: Employed in the development of chemical probes and affinity tags for studying biological processes and protein function.
• Academic & Contract Research: A vital reagent for synthetic chemistry research in universities and CROs (Contract Research Organizations) exploring new coupling methodologies.
• Scale-up Process Development: Used in pilot plants and kilo labs for process optimization and the production of target molecules at larger scales.

Basic Information

Product Name	2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile
CAS No.	1220220-02-9
Molecular Formula	C12H14BClN2O2
Molecular Weight	264.51 g/mol
Synonyms	2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyanopyridine; 2-Chloro-5-(pinacolatoboryl)nicotinonitrile; 3-Cyano-2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(Pinacolatoboraneyl)-2-chloronicotinonitrile; 2-Chloro-5-(pinacolboronato)nicotinonitrile; 1220220-02-9 (CAS); Nicotinonitrile, 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Every batch of our 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile is produced under strict quality management protocols. We employ advanced analytical techniques including HPLC, NMR (1H, 13C, 11B), and GC-MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent moisture absorption and decomposition. Recommended storage temperature: 2-8°C (refrigerated) for optimal long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.