Description

4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a high-value organoboron building block, specifically a pyridine-substituted boronic ester, essential for modern synthetic chemistry. Its core value lies in enabling efficient, palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is primarily needed by pharmaceutical, agrochemical, and advanced materials research and development teams for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in constructing fluorinated pyridine cores found in various drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that incorporate fluorinated heterocycles for enhanced efficacy and stability.
• Material Science Research: Serves as a precursor for creating functional organic materials, including organic light-emitting diodes (OLEDs) and liquid crystals, where the pyridine-boronate moiety modifies electronic properties.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological systems, leveraging its bioisosteric potential and coupling reactivity.
• Cross-Coupling Reactions: Primarily utilized in Suzuki-Miyaura cross-coupling to form carbon-carbon bonds between the pyridine ring and various aryl or vinyl halides, enabling rapid diversification of chemical libraries.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the custom synthesis of complex, target-specific molecules on a commercial scale.

Basic Information

Product Name	4-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1220219-91-9
Molecular Formula	C11H15BFNO2
Molecular Weight	223.05 g/mol
Synonyms	3-Pyridineboronic acid, 4-fluoro-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; 4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-Fluoro-3-pyridinylboronic acid pinacol ester; (4-Fluoropyridin-3-yl)boronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-fluoropyridine; 4-Fluoro-3-pyridylboronic acid pinacol ester; PINACOL 4-FLUORO-3-PYRIDINEBORONATE
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance in cross-coupling applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.