Description

(1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropyl)Methanol is a high-value, advanced pharmaceutical intermediate featuring a unique cyclopropyl methanol group attached to a pinacol boronate ester. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl scaffolds. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly for oncology, CNS, and antiviral therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those requiring a cyclopropane moiety for metabolic stability or conformational restriction.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for forming carbon-carbon bonds between aromatic rings, essential for creating diverse chemical libraries for high-throughput screening.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve drug-like properties.
• Agrochemical Synthesis: Potential intermediate in the development of novel herbicides or fungicides with unique modes of action.
• Material Science Precursor: Can be utilized in the synthesis of organic electronic materials, such as polymers or small molecules for OLEDs, where the boronate group enables precise molecular architecture.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical and biotechnology industries with custom synthesis and scale-up services.

Basic Information

Item	Details
Product Name	(1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropyl)Methanol
CAS No.	1220219-36-2
Molecular Formula	C16H23BO3
Molecular Weight	274.17 g/mol
Synonyms	[4-(1-Hydroxymethylcyclopropyl)phenyl]boronic acid pinacol ester; (1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropyl)methanol; 4-(1-(Hydroxymethyl)cyclopropyl)benzeneboronic acid pinacol ester; (1-(4-(Pinacolatoboryl)phenyl)cyclopropyl)methanol; B-[4-(1-Hydroxymethylcyclopropyl)phenyl]boronic acid pinacol ester; CAS 1220219-36-2; Pinacol [4-(1-hydroxymethylcyclopropyl)phenyl]boronate
EINECS	Contact for details

Quality Control

Our (1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropyl)Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support compliance with ICH Q7 guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.