Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-(2,2,2-Trifluoroethyl)-1,2,3,6-Tetrahydropyridine is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester and a tetrahydropyridine scaffold. This compound is critical for enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, in the synthesis of complex bioactive molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those requiring the introduction of a pyridine or piperidine moiety.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile organoboron reagent for forming carbon-carbon bonds with aryl or vinyl halides, a cornerstone of modern medicinal chemistry.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides that incorporate nitrogen-containing heterocycles.
• Material Science: Potential precursor for creating functionalized polymers or organic electronic materials with specific chemical handles.
• Chemical Biology Probes: Enables the synthesis of labeled compounds or probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Supplied in development and commercial quantities to support route optimization and manufacturing campaigns.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-(2,2,2-Trifluoroethyl)-1,2,3,6-Tetrahydropyridine
CAS No.	1219931-41-5
Molecular Formula	C13H21BF3NO2
Molecular Weight	291.12 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2,2-trifluoroethyl)-3,6-dihydro-2H-pyridine; 1-(Trifluoroethyl)-4-(pinacolboron)-1,2,3,6-tetrahydropyridine; 4-Pinacolatoboryl-1-(2,2,2-trifluoroethyl)-1,2,3,6-tetrahydropyridine; 1-Trifluoroethyl-4-Bpin-tetrahydropyridine
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-(2,2,2-Trifluoroethyl)-1,2,3,6-Tetrahydropyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, and custom specifications to meet your specific project needs are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.