Description

Methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in constructing biaryl and heterobiaryl scaffolds common in drug molecules.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific boronate-containing intermediates.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological processes and diagnostics.
• Cross-Coupling Reactions: Specifically designed as a stable, air-handleable reagent for palladium-catalyzed Suzuki-Miyaura cross-coupling with various aryl/heteroaryl halides.
• Library Synthesis for Drug Discovery: Facilitates the rapid parallel synthesis of compound libraries for high-throughput screening in early-stage drug discovery programs.

Basic Information

Product Name	Methyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinate
CAS No.	1219832-48-0
Molecular Formula	C13H18BNO4
Molecular Weight	263.10 g/mol
Synonyms	Methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxylate; 2-Pyridinecarboxylic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinic acid methyl ester; Methyl 3-boronic acid picolinate pinacol ester; 3-Pinacolatoboryl picolinic acid methyl ester; 3-(Pinacolatoboryl)picolinic Acid Methyl Ester; Methyl 3-(pinacolatoboryl)picolinate
EINECS	Contact for details

Quality Control

Our Methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.