Description

Enrofloxacin‐D5 Hydroiodide is a deuterated internal standard of the veterinary fluoroquinolone antibiotic, Enrofloxacin, specifically labeled with five deuterium atoms. This compound is essential for ensuring the accuracy and reliability of quantitative analytical methods, particularly Liquid Chromatography-Mass Spectrometry (LC-MS/MS), in pharmacokinetic and residue studies. It is a critical tool for research laboratories, contract research organizations (CROs), and pharmaceutical companies involved in veterinary drug development, food safety testing, and regulatory compliance.

Application

• Quantitative Analytical Internal Standard: Primary use as a stable isotope-labeled internal standard for the precise quantification of Enrofloxacin and its metabolite Ciprofloxacin in biological matrices via LC-MS/MS.
• Veterinary Pharmacokinetic Research: Enables accurate measurement of drug absorption, distribution, metabolism, and excretion (ADME) in livestock and companion animals.
• Food Safety & Residue Analysis: Critical for monitoring and confirming Enrofloxacin residue levels in meat, milk, eggs, and honey to ensure compliance with maximum residue limits (MRLs).
• Method Development & Validation: Serves as a reference material for developing, optimizing, and validating robust analytical methods in regulatory and quality control laboratories.
• Metabolite Studies: Used in research to track and quantify the biotransformation of Enrofloxacin to Ciprofloxacin and other metabolites.
• Quality Control in Pharmaceutical Manufacturing: Can be employed as a reference standard for the quality control of Enrofloxacin active pharmaceutical ingredient (API) and finished dosage forms.

Basic Information

Product Name	Enrofloxacin‐D5 Hydroiodide
CAS No.	1219795-24-0
Molecular Formula	C19H17D5FN3O3 • HI
Molecular Weight	492.33 g/mol
Synonyms	1-Cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid-D5 hydroiodide; Baytril-D5 hydroiodide; Enrofloxacin (phenyl-D5) hydroiodide; Enrofloxacin-d5 HI; Enrofloxacin (ethyl-d5) hydroiodide; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid-d5 hydroiodide
EINECS	Contact for details

Quality Control

Our Enrofloxacin‐D5 Hydroiodide is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity. Each batch is comprehensively analyzed using advanced techniques including NMR, HPLC, and Mass Spectrometry to confirm identity, chemical purity, isotopic enrichment, and absence of interfering impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (deuterium incorporation)	≥98 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.