Description

4'-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Biphenyl-2-Ol is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound is valued for its role as a key precursor in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing biphenyl or substituted biphenyl scaffolds.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific biaryl motifs.
• Material Science: Serves as a monomer or precursor in the creation of organic electronic materials, such as those for OLEDs (Organic Light-Emitting Diodes) and semiconductors.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds between aryl groups.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Academic & Industrial R&D: A valuable reagent for synthetic organic chemists in both university laboratories and corporate R&D centers exploring new chemical entities.

Basic Information

Item	Details
Product Name	4'-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Biphenyl-2-Ol
CAS No.	1219741-54-4
Molecular Formula	C18H21BO3
Molecular Weight	296.17 g/mol
Synonyms	2-Hydroxy-4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl; 2'-Hydroxy-[1,1'-biphenyl]-4-boronic acid pinacol ester; [1,1'-Biphenyl]-2-ol, 4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-(2-Hydroxyphenyl)phenylboronic acid pinacol ester; Biphenyl-2-ol boronic acid pinacol ester derivative; 4'-Pinacolatoborylbiphenyl-2-ol
EINECS	Contact for details

Quality Control

Our 4'-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Biphenyl-2-Ol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.