Description

Fmoc-3-Fluoro-Dl-Tyrosine CAS NO 1219389-96-4 is a fluorinated, racemic amino acid derivative protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group, designed for advanced solid-phase peptide synthesis (SPPS). This engineered building block is critical for introducing fluorine atoms into peptide backbones, a key strategy for modulating biological activity, metabolic stability, and physicochemical properties in therapeutic candidates. It is an essential raw material for pharmaceutical R&D, particularly for medicinal chemists and peptide manufacturers developing novel drug candidates, diagnostic probes, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, stepwise construction of complex fluorinated peptides using Fmoc-chemistry protocols.
• Medicinal Chemistry & Drug Discovery: Used to synthesize peptide-based drug candidates where fluorine substitution is employed to enhance binding affinity, improve proteolytic stability, and fine-tune pharmacokinetic profiles.
• Biochemical Research: Serves as a precursor for creating fluorinated peptide analogs used in structure-activity relationship (SAR) studies, enzyme substrate/inhibitor design, and receptor mapping.
• Radiopharmaceutical Precursors: Acts as a synthon for developing 18F-labeled peptides for Positron Emission Tomography (PET) imaging, leveraging the fluorine atom for radiolabeling.
• Peptide Library Construction: Enables the generation of diverse peptide libraries containing fluorotyrosine residues for high-throughput screening in lead identification.
• Material Science: Can be incorporated into peptide-based biomaterials and surface coatings to alter hydrophobicity and self-assembly properties.

Basic Information

Product Name	Fmoc-3-Fluoro-Dl-Tyrosine
CAS No.	1219389-96-4
Molecular Formula	C25H22FNO5
Molecular Weight	435.45 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-fluoro-DL-tyrosine; Fmoc-3-F-DL-Tyr-OH; Fmoc-3-Fluoro-DL-Tyr-OH; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-fluorophenyl)propanoic acid; 3-Fluoro-DL-tyrosine, N-Fmoc derivative; Fmoc-DL-3-Fluorotyrosine; N-Fmoc-3-fluoro-DL-tyrosine; DL-3-Fluorotyrosine Fmoc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-3-Fluoro-Dl-Tyrosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (by 1H NMR and MS), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere or with desiccant for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.