Description

7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2H-Benzo[B][1,4]Oxazin-3(4H)-One is a high-value boronic ester derivative, serving as a critical synthetic intermediate in modern organic and medicinal chemistry. Its core value lies in enabling efficient cross-coupling reactions, specifically Suzuki-Miyaura couplings, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing the benzoxazinone pharmacophore.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds to attach complex aryl groups, crucial for creating novel drug candidates and organic electronic materials.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific aromatic heterocyclic structures.
• Material Science: Serves as a precursor for organic semiconductors, OLED materials, and other functional polymers where precise molecular design is paramount.
• Chemical Biology & Probe Development: Utilized in creating molecular probes and labeled compounds for biochemical assays and diagnostic research.
• Academic & Contract Research: A vital reagent for synthetic methodology development and exploratory research in university and CRO laboratories.

Basic Information

Product Name	7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2H-Benzo[B][1,4]Oxazin-3(4H)-One
CAS No.	1219130-57-0
Molecular Formula	C₁₄H₁₈BNO₄
Molecular Weight	275.11 g/mol
Synonyms	7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-one; 7-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-1,4-benzoxazin-3(4H)-one; 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4H-benzo[b][1,4]oxazin-3-one; 7-Pinacolatoboryl-3,4-dihydro-2H-1,4-benzoxazin-3-one; 7-Boronobenzoxazinone pinacol ester; Benzoxazinone boronic ester; CAS 1219130-57-0
EINECS	Contact for details

Quality Control

Our 7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2H-Benzo[B][1,4]Oxazin-3(4H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.