Description

trans-4-Trifluoromethyl-Cyclohexylamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block. This compound is valued for its unique trifluoromethyl-substituted cyclohexylamine structure, which is critical for modulating the physicochemical and metabolic properties of target molecules. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients. The salt form offers enhanced stability and handling characteristics for precise process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of specialty polymers and advanced materials with tailored surface properties.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes and diagnostic agents in life science research.

Basic Information

Product Name	trans-4-Trifluoromethyl-Cyclohexylamine Hydrochloride
CAS No.	1218943-32-8
Molecular Formula	C7H13ClF3N
Molecular Weight	203.63 g/mol
Synonyms	trans-4-(Trifluoromethyl)cyclohexanamine hydrochloride; (1r,4r)-4-(Trifluoromethyl)cyclohexan-1-amine hydrochloride; 4-(Trifluoromethyl)cyclohexanamine hydrochloride (trans); 4-Trifluoromethylcyclohexylamine hydrochloride (trans); trans-4-Aminomethyl-alpha,alpha,α-trifluorotoluene hydrochloride; 4-(Trifluoromethyl)-1-cyclohexanamine hydrochloride (trans); (trans)-4-Trifluoromethylcyclohexylamine HCl
EINECS	Contact for details

Quality Control

Our trans-4-Trifluoromethyl-Cyclohexylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles. We support compliance with ICH guidelines and can tailor specifications to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.