Description

n-Isopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Amine is a high-value, protected boronic ester derivative of a substituted pyrimidine, serving as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds under mild conditions. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides requiring specific pyrimidine scaffolds.
• Material Science Research: Serves as a precursor for creating functionalized organic molecules used in organic light-emitting diodes (OLEDs) and liquid crystals.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and affinity tags for studying biological systems.
• Academic & Contract Research: A versatile reagent for methodology development and complex molecule synthesis in academic and industrial R&D laboratories.
• Scale-up Process Chemistry: Suitable for use in process optimization and pilot-scale synthesis of target molecules.

Basic Information

Product Name	n-Isopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Amine
CAS No.	1218791-46-8
Molecular Formula	C13H22BN3O2
Molecular Weight	263.15 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(propan-2-yl)pyrimidin-2-amine; 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-isopropylpyrimidine; N-Isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-isopropylpyrimidin-2-amine; Isopropyl-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-yl]-amine; CAS 1218791-46-8; Pinacol ester of 5-(Isopropylamino)pyrimidin-2-ylboronic acid
EINECS	Contact for details

Quality Control

Our n-Isopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment to guarantee traceability and compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a desiccated environment to prevent moisture absorption, which can affect stability and reactivity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.