Description

n-tert-Butyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Amine is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester reagent for forming carbon-carbon bonds between pyrimidine rings and various aryl or vinyl halides.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that incorporate functionalized pyrimidine cores.
• Material Science: Employed in the creation of organic electronic materials, such as those used in OLEDs and semiconductors, where precise molecular structure is crucial.
• Chemical Biology & Proteomics: Utilized as a building block for creating molecular probes and tool compounds to study biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring specific boronate functionality.

Basic Information

Product Name	n-tert-Butyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Amine
CAS No.	1218791-43-5
Molecular Formula	C14H24BN3O2
Molecular Weight	277.17 g/mol
Synonyms	2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine, N-tert-butyl derivative; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(tert-butyl)pyrimidin-2-amine; tert-Butyl[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl]amine; N-Boc-5-(Pinacolboron)pyrimidin-2-amine (common abbreviation); 5-Pinacolatoboron-N-tert-butylpyrimidin-2-amine; 1218791-43-5; Pyrimidine-2-amine, N-(1,1-dimethylethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our n-tert-Butyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.