Description

Benzyl 2-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critically important for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing drug candidates targeting a range of therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air-tolerant boronic ester reagent for forming carbon-carbon bonds under mild conditions.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides.
• Material Science: Intermediate for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Can be employed in the synthesis of molecular probes and activity-based protein profiling reagents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds at various scales.

Basic Information

Product Name	Benzyl 2-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenylcarbamate
CAS No.	1218791-42-4
Molecular Formula	C20H23BClNO4
Molecular Weight	387.66 g/mol
Synonyms	Benzyl N-[2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate; 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl benzylcarbamate; Benzyl (2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate; Pinacol [2-Chloro-4-(((benzyloxy)carbonyl)amino)phenyl]boronate; CAS 1218791-42-4
EINECS	Contact for details

Quality Control

Our Benzyl 2-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenylcarbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.