Description

n-(4-Amino-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide, Hcl is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic acid ester group. This compound is critical for facilitating efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, especially those requiring boronic acid functionality for coupling reactions.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl or vinyl boronic acids and halides, a cornerstone reaction in creating biaryl structures common in many APIs.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of linker molecules and warhead components for targeted protein degradation therapeutics.
• Agrochemical Research: Serves as an intermediate in the development of new herbicides and pesticides with specific modes of action.
• Material Science & OLED Development: A potential precursor for creating organic electronic materials and emissive layers in display technologies.
• Bioconjugation & Probe Synthesis: Utilized in the design of chemical probes and diagnostic agents for biological research and assay development.

Basic Information

Item	Details
Product Name	n-(4-Amino-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide, Hcl
CAS No.	1218791-41-3
Molecular Formula	C14H22BN2O3 • HCl
Molecular Weight	312.61 g/mol (Free base: 276.15 g/mol)
Synonyms	4'-Amino-2'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)acetanilide hydrochloride; 2-(4-Acetamido-3-aminophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane hydrochloride; N-[4-Amino-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide hydrochloride; B-Protected Aniline Acetamide Derivative; Pinacol Boronate Ester Intermediate; CAS 1218791-41-3
EINECS	Contact for details

Quality Control

Our production of n-(4-Amino-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide, Hcl adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure compliance with research and development grade standards. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container for extended periods to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.