Description

2,2,2-Trifluoro-1-(4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazin-1-Yl)Ethanone is a high-value, multi-functional organic building block that combines a trifluoroacetyl piperazine moiety with a pinacol boronate ester. This compound matters for its critical role as a key intermediate in modern synthetic chemistry, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction. Pharmaceutical, agrochemical, and advanced materials researchers need it for the efficient synthesis of complex molecules, enabling the development of new drugs, crop protection agents, and specialty polymers.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), especially those containing fluorinated and aryl-boronic acid motifs for targeted therapies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the Suzuki coupling for efficient structure-activity relationship (SAR) studies.
• Material Science Research: Serves as a precursor for creating advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where precise molecular architecture is required.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugates for diagnostic applications and biochemical pathway analysis.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form new carbon-carbon bonds, a cornerstone of modern organic synthesis.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries in medicinal chemistry for high-throughput screening against biological targets.

Basic Information

Product Name	2,2,2-Trifluoro-1-(4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazin-1-Yl)Ethanone
CAS No.	1218791-39-9
Molecular Formula	C20H28BF3N2O3
Molecular Weight	412.26 g/mol
Synonyms	1-[4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazin-1-yl]-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-[4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazin-1-yl]ethanone; 2,2,2-Trifluoro-1-(4-(4-(pinacolboranyl)phenyl)piperazin-1-yl)ethanone; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2,2,2-trifluoroacetyl)aniline piperazine derivative; Trifluoroacetylpiperazine phenylboronic acid pinacol ester; Boro-Piperazine Trifluoroacetyl Intermediate
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazin-1-Yl)Ethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.