Description

n-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Yl)Acetamide is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in developing novel pesticides and herbicides through structure-activity relationship (SAR) studies.
• Material Science: Serves as a monomer or functionalization agent in the creation of organic electronic materials and polymers.
• Chemical Biology: Employed in the design and synthesis of molecular probes and bioconjugates for target identification and validation.
• Academic & Contract Research: A vital reagent for methodology development and complex molecule synthesis in academic and industrial R&D laboratories.

Basic Information

Product Name	n-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Yl)Acetamide
CAS No.	1218791-37-7
Molecular Formula	C12H18BN3O3
Molecular Weight	263.11 g/mol
Synonyms	2-Acetamido-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; N-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl]acetamide; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine, N-acetyl derivative; Acetamide, N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrimidinyl]-; CAS 1218791-37-7; Pinacol ester of (2-Acetamidopyrimidin-5-yl)boronic acid
EINECS	Contact for details

Quality Control

Our n-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Yl)Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance in sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent hydrolysis of the boronic ester moiety.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.