Description

2-Ethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile is a high-value, multi-functional boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its primary commercial value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable intermediates for drug discovery, active ingredient synthesis, and the development of functional organic molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, especially in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require complex pyridine-based structures.
• Material Science: Serves as a precursor for organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors, where its boronic ester group facilitates polymerization and functionalization.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for constructing C-C bonds via palladium-catalyzed cross-coupling reactions.
• Ligand and Catalyst Development: Utilized in the synthesis of novel ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the custom production of complex target molecules.

Basic Information

Product Name	2-Ethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile
CAS No.	1218791-35-5
Molecular Formula	C14H19BN2O3
Molecular Weight	274.13 g/mol
Synonyms	3-Cyano-2-ethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-ethoxynicotinonitrile; 2-Ethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile; Pinacol 2-Ethoxy-3-cyanopyridine-5-boronate; 2-Ethoxy-3-cyano-5-pyridineboronic acid pinacol ester; 5-Boronic ester-2-ethoxy-3-cyanopyridine
EINECS	Contact for details

Quality Control

Our 2-Ethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR (1H and 13C), and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with REACH, FDA guidelines for drug intermediates, and other relevant global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere (argon or nitrogen) to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.