Description

2-(Benzyloxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), particularly in oncology and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the pyrimidine core is a common bioactive scaffold.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology & Proteomics: Employed as a versatile handle for bioconjugation and the synthesis of molecular probes for target identification and validation.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries for high-throughput screening in medicinal chemistry campaigns.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring specific boronate ester functionality.

Basic Information

Product Name	2-(Benzyloxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine
CAS No.	1218791-34-4
Molecular Formula	C₁₇H₂₁BN₂O₃
Molecular Weight	312.17 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(phenylmethoxy)pyrimidine; 2-Benzyloxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-(Benzyloxy)pyrimidine-5-boronic acid pinacol ester; Pyrimidine, 2-(benzyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1218791-34-4
EINECS	Contact for details

Quality Control

Every batch of 2-(Benzyloxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.