Description

Methyl 3,5-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, scalable building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the difluoro and boronate groups impart specific biological activity and stability.
• Material Science: Serves as a monomer or precursor for creating advanced polymers, liquid crystals, and organic electronic materials requiring specific fluorine and boron functionalities.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development, library synthesis, and exploring new chemical spaces via palladium-catalyzed cross-coupling reactions.
• Diagnostic Reagent Precursor: Utilized in the synthesis of probes and tags for bioimaging and diagnostic assays, leveraging its derivatization potential.

Basic Information

Product Name	Methyl 3,5-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate
CAS No.	1218791-32-2
Molecular Formula	C14H17BF2O4
Molecular Weight	298.10 g/mol
Synonyms	Methyl 3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid Methyl Ester; 4-Borono-3,5-difluorobenzoic Acid Methyl Ester, Pinacol Ester; Methyl 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,5-difluorobenzoate; 1218791-32-2; Benzoic acid, 3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3,5-Difluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Recommended long-term storage temperature is 2-8°C (refrigerated). Allow the sealed container to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.