Description

4,4,5,5-Tetramethyl-2-(2-Nitro-5-(Trifluoromethyl)Phenyl)-1,3,2-Dioxaborolane is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for researchers and process chemists in pharmaceutical R&D, agrochemical development, and the synthesis of organic electronic materials, where the introduction of complex, functionalized aromatic systems is required.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing trifluoromethyl and nitro-substituted aromatic motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient and selective formation of biaryl bonds, crucial for constructing complex molecular architectures in drug discovery.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage its unique aromatic substitution pattern.
• Material Science Research: Serves as a precursor for organic semiconductors, liquid crystals, and polymers where electron-withdrawing groups tune electronic properties.
• Chemical Biology & Probe Development: Utilized in creating molecular probes and tags for studying biological systems due to its borylation handle for further functionalization.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical and custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(2-Nitro-5-(Trifluoromethyl)Phenyl)-1,3,2-Dioxaborolane
CAS No.	1218791-26-4
Molecular Formula	C₁₃H₁₅BF₃NO₄
Molecular Weight	329.07 g/mol
Synonyms	2-(2-Nitro-5-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-Nitro-5-(trifluoromethyl)phenyl)boronic acid pinacol ester; 2-Nitro-5-(trifluoromethyl)benzeneboronic acid pinacol ester; 1-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-nitro-5-(trifluoromethyl)benzene; 2-Nitro-α,α,α-trifluoro-p-tolueneboronic acid pinacol ester; PINACOL [2-NITRO-5-(TRIFLUOROMETHYL)PHENYL]BORONATE
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(2-Nitro-5-(Trifluoromethyl)Phenyl)-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.