Description

n-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinamide is a high-purity boronic ester derivative of nicotinamide, serving as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable building blocks for drug discovery, ligand synthesis, and functional polymer development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require complex heterocyclic architectures.
• Material Science: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes, bioconjugation reagents, and activity-based protein profiling (ABPP) agents.
• Ligand & Catalyst Development: Acts as a precursor for creating sophisticated ligands used in transition metal catalysis and organocatalysis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	n-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinamide
CAS No.	1218791-25-3
Molecular Formula	C14H21BN2O3
Molecular Weight	276.14 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-methylnicotinamide; N-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carboxamide; 3-Pyridinecarboxamide, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-methyl-; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-methylnicotinamide; 5-BPin-N-methylnicotinamide; Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate amide (common misnomer); 1218791-25-3; M-5-TMDN
EINECS	Contact for details

Quality Control

Our n-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring material traceability and compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.