Description

n-tert-Butyl-2-Nitro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those requiring biaryl linkages.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a precursor for creating organic electronic materials and functional polymers.
• Cross-Coupling Reactions: Specifically designed as a reagent for palladium-catalyzed Suzuki-Miyaura couplings to introduce an aniline derivative into molecular frameworks.
• Chemical Biology Probes: Employed in the creation of tagged molecules for studying biological pathways and target engagement.
• Academic & Industrial R&D: A versatile tool for synthetic organic chemists exploring new chemical spaces and reaction methodologies.

Basic Information

Product Name	n-tert-Butyl-2-Nitro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline
CAS No.	1218791-23-1
Molecular Formula	C₁₆H₂₅BN₂O₄
Molecular Weight	320.20 g/mol
Synonyms	2-Nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(tert-butyl)aniline; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-tert-butyl-2-nitroaniline; N-(tert-Butyl)-2-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 1218791-23-1; Boronic acid, B-[2-nitro-4-[(1,1-dimethylethyl)amino]phenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; tert-Butyl[2-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]amine
EINECS	Contact for details

Quality Control

Our n-tert-Butyl-2-Nitro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.