Description

2,3-Difluoro-5-(Methoxycarbonyl)Phenylboronic Acid,Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a critical protected boronic acid building block, enabling precise cross-coupling reactions essential for constructing complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl and heterobiaryl structures.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those containing difluorinated aromatic systems.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced properties.
• Material Science Research: Employed in the development of organic electronic materials, such as polymers and small molecules for OLEDs or OFETs.
• Chemical Biology & Medicinal Chemistry: Facilitates the creation of chemical probes and library compounds for drug discovery and target validation.
• Process Chemistry & Scale-up: The pinacol ester group offers improved stability for handling and storage during large-scale manufacturing processes.

Basic Information

Product Name	2,3-Difluoro-5-(Methoxycarbonyl)Phenylboronic Acid,Pinacol Ester
CAS No.	1218791-19-5
Molecular Formula	C14H17BF2O4
Molecular Weight	298.10 g/mol
Synonyms	(5-(Methoxycarbonyl)-2,3-difluorophenyl)boronic acid pinacol ester; 2,3-Difluoro-5-(methoxycarbonyl)benzeneboronic acid pinacol ester; Methyl 2,3-difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 5-Carbomethoxy-2,3-difluorophenylboronic acid pinacol ester; Benzoic acid, 2,3-difluoro-5-(methoxycarbonyl)-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl ester
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-5-(Methoxycarbonyl)Phenylboronic Acid,Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent hydrolysis of the boronic ester moiety.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.